{"id":36338,"date":"2025-08-27T12:23:37","date_gmt":"2025-08-27T12:23:37","guid":{"rendered":"https:\/\/allonlinebanglanewspapers.com\/news\/24-7-market-news-lixte-showcases-lb-100-at-first-global-conference-on-oncogenic-signaling-activation-as-cancer-therapy\/"},"modified":"2025-08-27T12:23:37","modified_gmt":"2025-08-27T12:23:37","slug":"24-7-market-news-lixte-showcases-lb-100-at-first-global-conference-on-oncogenic-signaling-activation-as-cancer-therapy","status":"publish","type":"post","link":"https:\/\/allonlinebanglanewspapers.com\/news\/24-7-market-news-lixte-showcases-lb-100-at-first-global-conference-on-oncogenic-signaling-activation-as-cancer-therapy\/","title":{"rendered":"24\/7 Market News: LIXTE Showcases LB-100 at First Global Conference on Oncogenic Signaling Activation as Cancer Therapy"},"content":{"rendered":"<div id=\"main-body-container\" itemprop=\"articleBody\">\n<p>DENVER, Aug.  27, 2025  (GLOBE NEWSWIRE) &#8212; <strong>247marketnews.com<\/strong>, a pioneer in digital media dedicated to the swift distribution of financial market news and corporate information, highlights the publication of a new manuscript in <em>Trends in Cancer<\/em> (July 2025, Vol. 11, No. 7, <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=8LRuUG8WbHSFlzTC1epwUf-Tqkp-jsSwPLs40kBYihnXAFPWGBZnn3qNWyG7rs78ptzv7Yw8mezYG23L1Phn15XcW-uYlYEQ2s14H_ZPgK3oaOOyEY52xL8i85CeyfMe_dyLGAA2woERAxySSwkS50JOmE0dKJ0Ft_NfmMJCoAw=\" rel=\"nofollow\" target=\"_blank\" title=\"\">https:\/\/doi.org\/10.1016\/j.trecan.2025.04.009<\/a>) describing the first international conference on activation of oncogenic signaling as a cancer treatment strategy.<\/p>\n<p>The landmark meeting was co-sponsored by LIXTE Biotechnology Holdings, Inc. (NASDAQ: LIXT) and co-organized by Professor Rene Bernards, and board member of LIXTE. At the conference, compelling new data was presented showing that LIXTE\u2019s lead compound LB-100 can mediate activation of oncogenic signaling, a process that proves toxic to cancer cells.<\/p>\n<p><strong>A Paradigm Shift: Oncogenic Signaling as Therapy<\/strong><\/p>\n<p>Traditional cancer therapies have long focused on inhibiting oncogenic pathways. This meeting explored the counterintuitive strategy of activating these same pathways to push cancer cells beyond survival limits.<\/p>\n<p>LB-100, a first-in-class PP2A inhibitor, exemplifies this novel approach. By inhibiting PP2A, LB-100 removes a cellular \u201coff switch,\u201d triggering uncontrolled signaling activity in cancer cells. This \u201clethal activation\u201d drives cells into self-destruction, while also generating abnormal proteins (neoantigens) that make tumors more visible to immune attack.<\/p>\n<p><strong>LB-100: Expanding Validation Across Platforms<\/strong><\/p>\n<p>The conference reinforced the growing recognition of PP2A inhibition as a new therapeutic frontier. Presentations demonstrated:<\/p>\n<ul type=\"disc\">\n<li style=\"margin-top:5pt; margin-bottom:5pt;\">Oncogenic signaling activation: LB-100 induces hyperactivation of growth pathways that becomes unsustainable for tumor cells.<\/li>\n<li style=\"margin-top:5pt; margin-bottom:5pt;\">Cancer cell toxicity: This signaling overload leads directly to tumor cell death.<\/li>\n<li style=\"margin-top:5pt; margin-bottom:5pt;\">Combination potential: The mechanism creates synergy with immunotherapy and other treatment modalities.<\/li>\n<\/ul>\n<p>These findings further support LB-100\u2019s unique role as a platform therapy designed to enhance the effectiveness of multiple cancer treatments.<\/p>\n<p><strong>Positioning LIXTE as a Global Thought Leader<\/strong><\/p>\n<p>By co-sponsoring this first-of-its-kind meeting, LIXTE underscored its leadership in advancing innovative therapeutic strategies. The company\u2019s role as strategic organizer highlights its commitment to shaping the next chapter in cancer research.<\/p>\n<p><strong>About LIXTE Biotechnology Holdings, Inc.<\/strong><\/p>\n<p>LIXTE is a clinical-stage pharmaceutical company focused on discovering and developing innovative cancer therapies targeting the protein phosphatase 2A (PP2A) pathway, a previously underexplored avenue in cancer treatment. The company\u2019s lead compound, LB-100, is a first-in-class PP2A inhibitor that has demonstrated strong preclinical results and early-stage clinical tolerability. LIXTE is currently advancing a proof-of-concept trial in Ovarian Clear Cell Carcinoma.<\/p>\n<p>More information can be found at: <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=W1S_Ocj2E31A6KSdRZjB5N5Mz_m0dA8pjAcmrZD_Xrj1SYfcNg6iQg3Apdyp1wFBQs89LxLeR-uMr3bb5Qd2rw==\" rel=\"nofollow\" target=\"_blank\" title=\"www.lixte.com\">www.lixte.com<\/a><\/p>\n<p><strong>24\/7 MARKET NEWS, INC Disclaimer<\/strong><br \/>Please go to <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=8LRuUG8WbHSFlzTC1epwUUgQVUz-QGcVhoup8htFohAnNuepl05CzghCGXsnSwbO_VSek69FUVnN4cuweUDhp3l9Q7ncZGV12bBLzpp-7hSZQDiZmr906LUnP-IEnDZ9JXooBvM4yFakdrbAldl88BmaTbb_xwBcHL1235UXNWw=\" rel=\"nofollow\" target=\"_blank\" title=\"\">https:\/\/247marketnews.com\/lixte-biotechnology\/<\/a> for further LIXT information and 247marketnews.com LIXT disclosure information.<\/p>\n<p><strong>CONTACT:<\/strong><br \/>24\/7 Market News<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=ATvsbuYD_cJOBAVOQAe9uoG6aay7nqLUR17CH6ZOWNu9kMVgMoLhKV35iHcDkKF7w8fVYEJMj77uoup9mUhKQYmx08aNaDk7qhMEDeWZ-D20w-l9oEEQsmy0_0iHnDyE\" rel=\"nofollow\" target=\"_blank\" title=\"\"><u>Editor@247marketnews.com<\/u><\/a><\/p>\n<p><strong>Cautionary Note Regarding Forward-Looking Statements<\/strong><\/p>\n<p>This press release contains forward-looking statements that are subject to various risks and uncertainties. Such statements include statements regarding the Company&#8217;s ability to grow its business and other statements that are not historical facts, including statements which may be accompanied by the words &#8220;intends,&#8221; &#8220;may,&#8221; &#8220;will,&#8221; &#8220;plans,&#8221; &#8220;expects,&#8221; &#8220;anticipates,&#8221; &#8220;projects,&#8221; &#8220;predicts,&#8221; &#8220;estimates,&#8221; &#8220;aims,&#8221; &#8220;believes,&#8221; &#8220;hopes,&#8221; &#8220;potential&#8221; or similar words. Actual results could differ materially from those described in these forward-looking statements due to a number of factors, including without limitation, the Company&#8217;s ability to continue as a going concern, general economic conditions, and other risk factors detailed in the Company&#8217;s filings with the SEC. The forward-looking statements contained in this press release are made as of the date of this press release, and the Company does not undertake any responsibility to update such forward-looking statements except in accordance with applicable law.<\/p>\n<p>\n            <\/div>\n","protected":false},"excerpt":{"rendered":"<p>DENVER, Aug. 27, 2025 (GLOBE NEWSWIRE) &#8212; 247marketnews.com, a pioneer in digital media dedicated to the swift distribution of financial market news and corporate information, highlights the publication of a new manuscript in Trends in Cancer (July 2025, Vol. 11, No. 7, https:\/\/doi.org\/10.1016\/j.trecan.2025.04.009) describing the first international conference on activation of oncogenic signaling as a [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":36339,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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