{"id":23514,"date":"2024-11-12T12:03:52","date_gmt":"2024-11-12T12:03:52","guid":{"rendered":"https:\/\/allonlinebanglanewspapers.com\/news\/medigene-presents-data-on-an-innovative-ifn-%ce%b3-biosensor-technology-at-sitc-2024\/"},"modified":"2024-11-12T12:03:52","modified_gmt":"2024-11-12T12:03:52","slug":"medigene-presents-data-on-an-innovative-ifn-%ce%b3-biosensor-technology-at-sitc-2024","status":"publish","type":"post","link":"https:\/\/allonlinebanglanewspapers.com\/news\/medigene-presents-data-on-an-innovative-ifn-%ce%b3-biosensor-technology-at-sitc-2024\/","title":{"rendered":"Medigene Presents Data on an Innovative IFN-\u03b3 Biosensor Technology at SITC 2024"},"content":{"rendered":"
\n

Planegg\/Martinsried, November 12, 2024.<\/b> Medigene AG<\/u><\/a> (Medigene or the \u201cCompany\u201d, FSE: MDG1, Prime Standard), an oncology platform company focused on the research and development of T cell receptor (TCR)-guided therapies for the treatment of cancer, presented data on the newest addition to its End-to-End (E2E) Platform, an Interferon-Gamma (IFN-\u03b3) Biosensor technology that allows real-time monitoring and quantification of IFN-\u03b3 release from cytokine-secreting cells at the Society of Immunotherapy of Cancer (SITC) 2024 Conference taking place in Houston, TX, USA from November 6-10, 2024. <\/p>\n

The poster \u201cThe IFN-\u03b3 Biosensor \u2013 A universal tool for IFN-\u03b3 detection in cellular co-culture assays\u201d<\/i><\/strong> is available on Medigene\u2019s website: https:\/\/medigene.com\/science\/abstracts\/<\/u><\/a><\/p>\n

\u201cRelease of IFN-\u03b3 is one of the most common parameters used to measure T cell or NK cell functionality. Current methods for detection of IFN-\u03b3 secretion have several drawbacks, including extensive hands-on-time and needs for expensive, temperature-sensitive reagents,\u201c said Dolores Schendel, CSO of Medigene AG. \u201cThe IFN-\u03b3 Biosensor is an innovative tool within our E2E Platform that provides a simple, low-cost, cell-based alternative for quantification of secreted IFN-\u03b3. This biosensor addresses limitations of current methods by reducing time, costs and complexity. The biosensor cells can be added directly as third-party bystander cells to co-cultures of T or NK cells, thereby dramatically reducing assay steps while enabling a dynamic assessment of IFN-\u03b3 secretion over time, going beyond standard end-point assays.\u201d The presented poster displayed a direct comparison between the conventional standard method Enzyme-linked Immunosorbent Assay (ELISA) and the Company\u00b4s proprietary innovative IFN-\u03b3 Biosensor to determine IFN-\u03b3 release directly in cell co-cultures or in cell supernatants. The biosensor cells were generated to produce a green fluorescent protein (GFP) when exposed to IFN-\u03b3 and allow for quantitative analysis of the GFP fluorescent reporter signal<\/p>\n

The IFN-\u03b3 biosensor demonstrated comparable sensitivity to ELISA, effectively detecting low levels of IFN-\u03b3 using standard measurement tools like flow cytometry and fluorescence readings. Detection was highly specific for IFN-\u03b3, with minimal response observed only when exposed to exceedingly high levels of IFN-\u03b1 or IFN-\u03b2, two other interferon types. Further in vitro assays showed that the biosensor produced dose-dependent results comparable to ELISA, that were stable and sensitive to IFN-\u03b3 stimulation over extended co-culture periods. The addition of this process optimization technology to the Medigene End-to-End Platform significantly reduces costs and complexity while increasing speed and reproducibility when applied in high-throughput screening assays of T or NK cell functionality. The time from assay completion to analysis of results was significantly reduced, providing faster data processing and is more efficient and streamlined when implemented in robotic workflows.<\/p>\n

Overall, with its broad detection range, dynamic measurements over time, and high specificity, the IFN-\u03b3 Biosensor technology to provide a sensitive and efficient alternative that extends beyond a traditional ELISA for measuring T cell and NK cell functionality. Simple readouts using either flow cytometry and fluorescence readers-supports its easy integration in high-throughput workflows, cutting costs and handling times.<\/p>\n

—\u00a0 end of press release\u00a0 —<\/i><\/p>\n

About Medigene AG<\/b><\/p>\n

Medigene AG (FSE: MDG1) is an immuno-oncology platform company dedicated to developing T cell receptor (TCR)-guided therapies to effectively eliminate cancer. Its End-to-End Platform generates optimal 3S (sensitive, specific and safe) T cell receptors with unique and distinctive attributes that are utilized in multiple therapeutic modalities, such as T cell receptor engineered T cell (TCR-T) therapies, TCR-guided T cell engager therapies and TCR-natural killer cell therapies for both its in-house product pipeline and partnering.<\/p>\n

Medigene\u2019s lead TCR-T program MDG1015 is a potential best-in-class, TCR-T therapy to treat multiple solid tumor indications. The End-to-End Platform technologies enable armoring and enhancing of these T cells to overcome the immunosuppressive tumor microenvironment (TME) and ensure the T cell drug product composition maximizes safety, efficacy and durability of response. Medigene\u2019s MDG1015 received IND approval in Q3 2024 and is filing for CTA in Q4 2024. For more information, please visit https:\/\/medigene.com\/<\/u><\/a> <\/p>\n

About Medigene\u2019s End-to-End Platform<\/b><\/p>\n

Medigene\u2019s approach to immunotherapy harnesses the immense power of natural T cell receptors. By combining these TCRs with different components of the immune system such as T cells, natural killer (NK) cells or a CD3 complex (TCE, T cell engager), highly specific, sensitive and safe modalities are formed to either complement and\/or activate the body\u2019s defense systems against cancer. Medigene\u2019s comprehensive End-to-End (E2E) Platform is built on a foundation of proprietary and cutting-edge technologies, driving the development of highly specific TCR-guided therapies, including the latest advancements in TCR-T, TCR-NK and TCR-TCE drug products. The E2E Platform incorporates sophisticated TCR generation and optimization techniques, such as Allogeneic-HLA TCR Priming, and integrates advanced product armoring and enhancement features like PD1-41BB and CD40L-CD28 Costimulatory Switch Proteins, and iM-TCR. In addition, the E2E Platform offers solutions to developing optimal cell therapy drug products for improved safety, efficacy and durability. Collaborations with partners like BioNTech, Regeneron and WuXi Biologics further underscore the platform\u2019s capabilities and its potential to revolutionize cancer treatment.<\/p>\n

This press release contains forward-looking statements representing the opinion of Medigene as of the date of this release. The actual results achieved by Medigene may differ significantly from the forward-looking statements made herein. Medigene is not bound to update any of these forward-looking statements. Medigene\u00ae<\/sup> is a registered trademark of Medigene AG. This trademark may be owned or licensed in select locations only.<\/i><\/p>\n

Medigene AG<\/b><\/p>\n

Pamela Keck
Phone: +49 89 2000 3333 01
E-mail: investor@medigene.com<\/u><\/p>\n

In case you no longer wish to receive any information about Medigene, please inform us by e-mail (investor@medigene.com<\/u><\/a>). We will then delete your address from our distribution list.<\/p>\n

\n <\/div>\n","protected":false},"excerpt":{"rendered":"

Planegg\/Martinsried, November 12, 2024. Medigene AG (Medigene or the \u201cCompany\u201d, FSE: MDG1, Prime Standard), an oncology platform company focused on the research and development of T cell receptor (TCR)-guided therapies for the treatment of cancer, presented data on the newest addition to its End-to-End (E2E) Platform, an Interferon-Gamma (IFN-\u03b3) Biosensor technology that allows real-time monitoring 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